Abstract Regulation of the Hedgehog pathway activity may be supported Full Quilt Set by coactivators and corepresors of its main effectors- Gli transcription factors.While activation processes are well studied, repression mechanisms remain elusive.We identified chromatin remodelling complex Hira to interact with Gli3R protein, showed that its loss-of-function changes Hh pathway activity, and examined possible mechanism behind the Round Cake Pans observed effect.We also established that Hira influences the viability and migratory abilities of Hh-dependent medulloblastoma Daoy cells.
Our study paves the way for a better understanding of processes involved in Hh pathway regulation and Hh-dependent carcinogenesis.